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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Ann Neurol. 2013 Jun 19;74(1):20–38. doi: 10.1002/ana.23937

Table 1.

ALS autopsy cases (N=76) included in this study; data is shown as median and interquartile range (in parentheses).

Site of onset ALS (all) BLMN BUMN CLMN LLMN LUMN
N 76 16 6 25 19 10
Gender [f/m] 30/46 5/11 3/3 9/16 9/10 4/6
Duration [mo] 33 (24-60) 30 (23-39) 24 (23-33) 30 (22-46) 34 (30-62) 58 (28-96)*
Age at death [yrs] 63 (56-70) 66 (60-71) 64 (46-72) 62 (55-71) 61 (58-66) 58 (56-74)
ALSFRS-R 18 (14-23) 24 (14-26) 24 (19-30) 18 (15-22) 17 (14-23) 21 (13-27)
MMSE 29 (26-30) 29 (27-30) 25 (24-28) 29 (28-30) 28 (27-29) 29 (28-30)
Brain weight [g] 1353
(1231-
1427)		 1359
(1333-
1453)		 1352
(11258-
1473)		 1365
(1222-
1456)		 1323
(1252-
1420)		 1233
(1162-
1388)
*

Statistical significance across ALS syndromes in Kruskal-Wallis One Way Analysis of Variance on Ranks, p = 0.02. Abbreviations: ALSFRS-R – ALS functional rating scale, revised version, BLMN – bulbar lower motor neuron onset of disease, BUMN – bulbar upper motor neuron onset of disease, CLMN – cervical lower motor neuron onset of disease, duration – duration of disease, f/m – female/male, g – grams, LLMN – lumbar lower motor neuron onset of disease, LUMN – lumbar upper motor neuron onset of disease, mo – months, yrs – years.