Figure 8.

Lineal relationships, molecular profiles, and morphologies of neocortical precursor cells. In addition to generating neurons directly (black), our results indicate that RGCs generate several classes of intermediate progenitors. SNPs (red) lack basal processes and divide within the VZ at the ventricular surface after first being generated from RGC parent cells (blue). Both RGCs and SNPs express Pax6. While RGCs are thought to self-renew, SNPs divide once to generate two neuronal daughter cells which then migrate radially into the neocortical wall, indicating that they are a class of intermediate neural progenitors. Our fate mapping and time-lapse imaging study indicates that bRG (green) are derived from RGCs and express Pax6 and divide in the SVZ. While bIPCs (yellow) are also derived from RGCs, they are distinguished by their multipolar morphology, expression of Tbr2, and abventricular divisions.