Table 2.

Expansion of mHA-specific Tregs

		mHA-specific Treg FPM*
Sibling pair	Samples from blood/apheresis	Before culture	After culture	mHA-specific Treg fold expansion
1	Blood	28	18 182	405
2	Blood	50	11 111	167
3	Blood	91	14 925	155
4	Blood	30	14 225	358
Median	Blood	40	14 575	263
Range		(28-91)	(11 111-18 182)	(155-405)
5	Apheresis	70	27 248	324
6	Apheresis	19	8475	405
7	Apheresis	46	17 762	336
8	Apheresis	74	15 765	212
Median	Apheresis	58	16 764	330
Range		(19-74)	(8475-27 248)	(212-405)

FPM, frequency per million.

^*mHA-specific Treg frequencies were calculated by LDA of purified Tregs before and 12 days after culture.