Figure 3.

Impaired hepatic fatty acid β-oxidation activity in ArKO mice. Peroxisomal β-oxidation capacity was assessed using tetracosanoic acid (C24:0) as the substrate, and mitochondrial β-oxidation capacity, using palmitic acid (C16:0) and lauric acid (C12:0). The bars represent the mean ± SD from at least six samples in each group. ^AStatistically significant difference (P < 0.001) compared with the value obtained with the wild-type group (Ar^+/+) and the ArKO mice supplemented with 17β-estradiol group (Ar^–/– + E2).