Figure 2.

Physiological characteristics of male C57BL/6J mice fed high-fat (n = 22) and low-fat (n = 22) diets. Dietary treatment began when mice were 4 weeks old and lasted for 15 weeks. Filled circles represent a diet of 45% fat; open circles represent a diet of 10% fat. Data are presented as mean ± SEM. (a) Effects of diets on body weight. ^AFirst day of significant weight difference (P < 0.001) between mice fed 10% fat and those fed 45% fat. (b) Caloric intake on the two diets. ^AP < 0.05. (c) Effects of diets on serum leptin concentration. ^AP < 0.001.