Table 1.
Serum concentrations of tamoxifen and its metabolites correlate with age
| Tamoxifen | 4OHtama | 4OHNDtam | NDtam | NDDtam | TamNox | |
|---|---|---|---|---|---|---|
| Serum concentrations (ng/ml)b | ||||||
| All (n = 151) | 89.9 (27.1–302.1) | 5.7 (1.7–17.2) | 49.6 (24.3–184.8) | 225.7 (90.1–690.9) | 37.0 (11.4–93.4) | 9.4 (2.7–37.9) |
| Wt/Wt EM (n = 86) | 90.5 (33.9–291.1) | 5.8 (2.2–17.2) | 52.3 (24.3–184.8) | 216.7 (90.1–596.3) | 37.7 (11.4–93.4) | 9.0 (3.2–29.0) |
| Correlations with age (R(p))c | ||||||
| All (n = 151) | 0.163 (0.045) | 0.120 (0.141) | 0.195 (0.017)) | 0.207 (0.011) | 0.260 (0.001) | 0.112 (0.172) |
| Wt/Wt EM (n = 86) | 0.203 (0.060) | 0.190 (0.080) | 0.285 (0.008) | 0.250 (0.020) | 0.263 (0.014) | 0.191 (0.079) |
a 4OHtam 4-hydroxytamoxifen, 4OHNDtam 4-hydroxy-N-demethyltamoxifen, NDtam N-demethyltamoxifen, NDDtam N-dedimethyltamoxifen, tamNox tamoxifen-N-oxide, Wt/Wt EM wild type/wild type extensive metabolizer CYP2D6
b Median (range)
c R and p values are derived from two-tailed Spearman correlation rank test