. Author manuscript; available in PMC: 2013 Sep 27.

Published in final edited form as: J Mol Biol. 2012 Nov 15;425(2):444–456. doi: 10.1016/j.jmb.2012.11.010

Table 2.

Mutations that disrupt binding to CD4 binding site-directed antibodies.

Antibody	Highly-disruptive mutations	Weak mutations
VRC01	D368R	S365K T455E G459E D461I G473R
b12	D368R R419G T455E	K282V S365K I467K
b13	D368R	R419G