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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: J Allergy Clin Immunol. 2013 Jul 4;132(2):400–11.e9. doi: 10.1016/j.jaci.2013.05.029

Figure 3. Cytokine-induced expression of granzyme B is impaired in IL-21R-deficient or STAT3-deficient naïve CD8+ T cells.

Figure 3

Naïve CD8+ T cells were cultured with cyokines only and (A and B) graphs depict fold increase (mean ± SEM; n=5) in MFI of granzyme B over normal cells cultured with media alone (A). Each bar graph in (B) represents mean and range of duplicate cultures from an individual patient or normal donor for experiments using cells from STAT1- and IL-21R deficient patients. (A) and (C) are representative plots of cells from normal donors or the indicated patients stimulated with IL-21/IL-15 and normal donor cells from unstimulated cultures. ** P<0.001; *** P<0.001.