Table 5.
Significant associations between single nucleotide polymorphisms within linkage peaks and metabolic traits in the study population.
| Trait | SNP | Chromosome | Gene | P (Add)1 | P (Full)2 | P(Int) 3 |
|---|---|---|---|---|---|---|
| ApoA2 | ||||||
| rs1317423 | 4 | -- | 0.0009 | 0.009 | 0.48 | |
| HDL | ||||||
| rs713144 | 3 | -- | 0.002 | 0.01 | 0.38 | |
| rs2475793 | 10 | NRG3 | 0.0003 | 0.006 | 0.63 | |
| rs535534 | 13 | POLR1D | 0.001 | 0.005 | 0.24 | |
| rs2194198 | 19 | -- | 0.0009 | 0.001 | 0.50 | |
| Total cholesterol | ||||||
| rs728919 | 11 | NAA40 | 0.003 | 0.06 | 0.97 | |
| rs562865 | 11 | MACROD1 | 0.003 | 0.06 | 0.94 | |
1
Model included sex, age, n-3 PUFA intake, community group, and additive genetic term.
2
Model included all terms listed above plus an interaction between the additive genotype and n-3 PUFA intake.
3
P-value from the likelihood ratio test for interaction between the additive genotype and n-3 PUFA intake.