Figure 8.

Ncc T58M mutation reversed the phenotype of the PHAII with Wnk4 D561A mutation. Representative phenotype including mean BP, plasma aldosterone (Aldo), bicarbonate [HCO₃⁻], potassium [K⁺], magnesium [Mg²⁺], total calcium [Ca²⁺] concentration, and urinary fraction excretion of potassium [FEK], magnesium [FEMg], and urine Ca²⁺ to creatinine ratio (UCa²⁺/Cr) in WT, Ncc T58M homozygous knock-in, Wnk4 D561A heterozygous knock-in, and Ncc T58M homozygous with Wnk4 D561A heterozygous double knock-in mice (n=6/group).