Figure 2.

NaDC-1 mediated Na⁺-succinate cotransport is inhibited by slc26a6. (A) Representative traces. (B) Summary of the current mediated by NaDC-1-dependent Na⁺-succinate cotransport in oocytes expressing NaDC-1 alone (black) or coexpressed with slc26a6 (gray) or slc26a3 (light gray). The transport was initiated by the addition of 1 mM succinate to the perfusate, as indicated. (C) Surface expression of NaDC-1(Flag) in the presence and absence of slc26a6. Note that the coexpression with slc26a6 has no effect on surface NaDC-1. (D) Reciprocal Co-IP of NaDC-1(Flag) and slc26a6(GFP). Expression in HEK cells was used for surface expression and Co-IP.