Table 5.
Position | SNP ID | Publication | A1 | Reported per- allele ORa |
Reported p-value |
Pooled per- allele OR |
Pooled p-value |
---|---|---|---|---|---|---|---|
9p22.2 | rs3814113 | Song et al, (2009) | C | 0.77 (0.73-0.81) | 4.1e-21 | 0.86 (0.72-1.05) | 0.082 |
19p13 | rs8170 | Bolton et al, (2010) | C | 1.18 (1.12-1.25) | 2.7e-09 | 0.97 (0.77-1.31) | 0.175 |
rs2363956 | G | 1.16 (1.11-1.21) | 3.8e-11 | 0.92 (0.78-1.12) | 0.60 | ||
2q31 | rs2072590 | Goode et al, (2010) | T | 1.20 (1.14-1.25) | 3.8e-14 | 1.21 (1.01-1.41) | 0.03 |
3q25 | rs2665390 | C | 1.24 (1.15-1.34) | 7.1e-08 | 1.22 (0.93-1.79) | 0.060 | |
8q24 | rs10088218 | A | 0.76 (0.70-0.81) | 8.0e-15 | 1.28 (0.89-1.66) | 0.882 | |
17q21 | rs9303542 | G | 1.14 (1.09-1.20) | 1.4e-07 | NAb | NAb |
For a direct comparison of results, reported per-allele ORs are the results from the published GWAS restricted to serous cases.
rs9303542 was not on Illumina Human 1Mduo array, but rs6504172 is in high linkage disequilibrium with rs9303542 (r2=0.841). It had a per-allele OR in the pooled GWAS of 1.10 (0.84-1.56) (P=0.49).