Table 5.
Pooled GWAS results on the published loci known to be associated with serous ovarian cancer susceptibility
| Position | SNP ID | Publication | A1 | Reported per- allele ORa |
Reported p-value |
Pooled per- allele OR |
Pooled p-value |
|---|---|---|---|---|---|---|---|
| 9p22.2 | rs3814113 | Song et al, (2009) | C | 0.77 (0.73-0.81) | 4.1e-21 | 0.86 (0.72-1.05) | 0.082 |
| 19p13 | rs8170 | Bolton et al, (2010) | C | 1.18 (1.12-1.25) | 2.7e-09 | 0.97 (0.77-1.31) | 0.175 |
| rs2363956 | G | 1.16 (1.11-1.21) | 3.8e-11 | 0.92 (0.78-1.12) | 0.60 | ||
| 2q31 | rs2072590 | Goode et al, (2010) | T | 1.20 (1.14-1.25) | 3.8e-14 | 1.21 (1.01-1.41) | 0.03 |
| 3q25 | rs2665390 | C | 1.24 (1.15-1.34) | 7.1e-08 | 1.22 (0.93-1.79) | 0.060 | |
| 8q24 | rs10088218 | A | 0.76 (0.70-0.81) | 8.0e-15 | 1.28 (0.89-1.66) | 0.882 | |
| 17q21 | rs9303542 | G | 1.14 (1.09-1.20) | 1.4e-07 | NAb | NAb |
a
For a direct comparison of results, reported per-allele ORs are the results from the published GWAS restricted to serous cases.
b
rs9303542 was not on Illumina Human 1Mduo array, but rs6504172 is in high linkage disequilibrium with rs9303542 (r2=0.841). It had a per-allele OR in the pooled GWAS of 1.10 (0.84-1.56) (P=0.49).