Table 2.
Cardiovascular History, Overall and Stratified by Receipt of Cardiotoxic Agents
| VARIABLE | TOTAL | CARDIOTOXIC1 | NOT CARDIOTOXIC |
|---|---|---|---|
|
| |||
| N (%)2 | N (%)2 | N (%)2 | |
|
| |||
| ALL PATIENTS: N (%) | 285 (100) | 193 (67.7) | 92 (32.3) |
|
| |||
| Any Pre-existing/concurrent CV comorbidity3 | |||
| Yes | 53 (100) | 20 (37.7) | 33 (62.3) |
|
| |||
| No | 232 (100) | 173 (74.6) | 59 (25.4) |
|
| |||
| Decreased LVEF4 before first breast cancer treatment5 | |||
| Yes | 11 (100) | 6 (54.5) | 5 (45.5) |
|
| |||
| No | 158 (100) | 130 (82.3) | 28 (17.7) |
|
| |||
| Not evaluated6 | 116 (100) | 57 (49.1) | 59 (50.9) |
| History of Events before first breast cancer treatment5 | |||
| Overall Cardiac Event7 | 55 (100) | 22 (40.0) | 33 (60.0) |
|
| |||
| Heart Failure Event8 | 23 (100) | 6 (26.1) | 17 (73.9) |
|
| |||
| Dysrhythmia Event9 | 21 (100) | 7 (33.3) | 14 (66.7) |
|
| |||
| Ischemia Event10 | 32 (100) | 14 (43.8) | 18 (56.2) |
Cardiotoxic agents: doxorubicin (Adriamycin), mitoxantrone (Novantrone), trastuzumab (Herceptin); no patients were exposed to epirubicin.
Percentages based on row total.
Medical record documentation that any of the following conditions were present on or before the date of first breast cancer diagnosis: CHF, cardiomyopathy, decreased LVEF < 50%, myocarditis, cardiac arrest, heart block, arrhythmia, CAD, MI, angina or cardiac ischemia.
Decreased Left Ventricular Ejection Fraction is defined as ejection fraction <50%.
Exposure to drug category (i.e. cardiotoxic or not cardiotoxic). Patients exposed to both cardiotoxic and non-cardiotoxic drugs included in the cardiotoxic column of this table.
Among the 57 patients who received cardiotoxic chemotherapy and did not have LVEF measured before treatment initiation, 56 did not have a history of cardiac disease, heart failure, or ischemia according to medical record review. Only 1 patient had a history of dysrhythmia.
Overall Cardiac Event defined as history of Heart Failure, Dysrhythmia or Ischemia Events combined
Heart Failure Event defined as history of CHF, cardiomyopathy, decreased LVEF <50%, or myocarditis
Dysrhythmia Event defined as history of cardiac arrest, heart block, or arrhythmia.
Ischemia Event defined as history of CAD, MI, angina or cardiac ischemia.