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. Author manuscript; available in PMC: 2013 Sep 27.
Published in final edited form as: Dev Dyn. 2004 Aug;230(4):754–766. doi: 10.1002/dvdy.20083

Fig. 6.

Fig. 6

Reduced germ cell proliferation in RARα−/− young adult mice as shown by in vivo bromodeoxyuridine (BrdU) labeling. A–F: Histological sections of 8-week-old testis from RARα+/+ (A,C,E,F) and RARα−/− mice (B,D) 1 day after BrdU injection (see Experimental Procedures section). Strong BrdU labeling was noted in the proliferating spermatogonia and preleptotene spermatocytes in many of seminiferous tubules of 8-week-old RARα+/+ testes (A,C,E,F). Arrows in C point to preleptotene spermatocytes. Arrow in D points to spermagonia. Arrows in F point to zygotene spermatocytes. A,B: Original magnification, ×20. C–F: Original magnification, ×40. SG, spermatogonia; A3 and A4, A3 and A4 spermatogonia, respectively; P, pachytene spermatocytes; L, leptotene spermatocytes; PL/L, preleptotene or leptotene spermatocytes; D, diplotene spermatocytes; Z, zygotene spermatocytes. Arabic numerals indicate the step of spermatid differentiation. Roman numerals indicate the stage of the seminiferous tubules.