Figure 5. ovo is expressed in a population of homeostatic eye progenitors.
(A) In starved intact animals, ovo is expressed in isolated dorsal cells between the eyes and pharynx. These cells are eliminated within 24 hours of irradiation.
(B) ovo+ cells posterior to the eyes in intact animals also express six-1/2 and eya.
(C) ovo+ cells posterior to the eyes in intact animals also express the neoblast marker histone h2b (60% +/− 15%, α =0.05).
(D) ovo(RNAi) animals that are not amputated fail to maintain eyes (n=10/10).
(E)–(F) ovo(RNAi) animals that are not amputated fail to maintain six-1/2+/eya+ cells posterior to the eyes (n=4 animals). For image clarity only six-1/2 signal is shown.
(G)–(H) six-1/2(RNAi) and eya(RNAi) animals fail to maintain ovo+ cells posterior to the eyes (n=4 animals).
Arrows indicated double-positive cells in (B) and (C). Error bars represent SD. *** p < .005. Scale bars, 100 µm (A), 50 µm (B,C,F,H), and 200 µm (D).