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. Author manuscript; available in PMC: 2013 Sep 27.
Published in final edited form as: Am J Transplant. 2007 Feb 7;7(5):1055–1061. doi: 10.1111/j.1600-6143.2006.01703.x

Figure 4. Absolute counts of naïve and memory T-cell subsets after DBMT in Group B (n = 2) and Group C recipients (n = 3).

Figure 4

(A) CD4 naïve T cells were effectively depleted and remained suppressed. (B) The absolute counts of CD4 effector memory T cells (CD95+CD28 & minus; CD4Tem remained low in the peripheral blood. (C) CD4 central memory T cells (CD95+CD28+, CD4Tcm were resistant to the conditioning regimen and their absolute counts remained >200/mm3 in both Groups B and C. (D) CD8 naïve T cells (CD95−) were effectively depleted and remained suppressed after DBMT in both Groups B and C, regardless of cM-T807 treatment. (E) CD8 effector memory T cells (CD95+CD28−, CD8 TEM) were effectively depleted until day 5 in both groups. However, rapid expansion of CD8 TEM ensued thereafter in Group B, while such rapid expansion of CD8 TEM was effectively inhibited by cM-T807 treatment in Group C. (F) Absolute counts of CD8 TCM were also more suppressed in Group C than those in Group B.