Table 1. Conditioning regimens and induction of multilineage chimerism.
Regimen | Conditioning and DBMT1 | Multilineage Chimerism | |||||
---|---|---|---|---|---|---|---|
| |||||||
N | TBI (1.5Gy × 2) | TI (7Gy) | DBMT | cM-T807 | |||
SKBMT | 8 | Days −5 and −62 | Day −1 | Day 0 | − | 8/8 | |
Delayed | A | 4 | Day +1, +2 | Day +5 | Day +6 | − | 0/4 |
B | 3 | +4 Months | +4 Months | +4 Months | − | 0/3 | |
C | 5 | +4 Months | +4 Months | +4 Months | + | 3/5 |
All recipients were also treated with ATGAM and anti-CD154 administration, followed by a 1-month course of calcineurin inhibitor after DBMT.
Relative to the time of kidney translplantation.