Table 1. Summary of biophysical characteristics of NKTT120.
Biacore affinity | |
---|---|
NKTT120 interaction partner | KD |
Hu iTCR | 44 nM |
FcγRI | 12 nM |
FcγRIII | 122 nM |
C1q | Minimal interaction, KD not determinable |
ADCC | |
NKTT120 [µg/ml] | (Cell killing) |
1 | 34% |
20 | 44% |
CDC | |
NKTT120 [µg/ml] | (Cell killing) |
1 | BLQ |
20 | 20% |
100 | 41% |