Figure 1.

Genomewide scan of 110 patients with schizophrenia from 33 families. The 110 patients included 106 who fulfilled the Research Diagnostic Criteria (RDC) schizophrenia diagnosis, three patients diagnosed with unspecified functional psychosis, and one diagnosed with schizoaffective disorder. With the assistance of our genealogical database, the patients were clustered into 33 families, and relations between patients are as distant as second cousins. The patients and their relatives were genotyped using a framework set of 950 microsatellite markers. The X-axis gives the genetic distance (in cM) along the chromosome, and the Y-axis gives the LOD score. The data were analyzed using multipoint allele-sharing, without specification of an inheritance model, using Allegro (Gudbjartsson et al. 2000).