Figure 4.

Microsatellite and SNP at-rick haplotypes at the 5′ end of the NRG1 gene. Four haplotypes, defined by 12 SNPs and four microsatellite markers, were individually found in excess in the schizophrenia patients with similar relative risk. The common core for these haplotypes, defined by five SNPs and two microsatellite markers, is shown at the bottom. The frequencies for each haplotype in all affected individuals, independent affected individuals, and control individuals are indicated in the panel on the right. The only known exon within the boundaries of the core at-risk haplotype is the 5′ exon of GGF2, as indicated in the figure. The distance between the markers flanking possible recombination breakpoints (arrows) is 290 kb, corresponding to 0.16–0.45 Mb on the scale at the bottom of figure 3.