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. 2013 Sep 27;8(9):e77227. doi: 10.1371/journal.pone.0077227

Figure 2. Evaluation of anti-inflammatory and antidepressants drugs in depressive-like behaviour and paw edema induced by CFA.

Figure 2

Effect of intraplantar injection of CFA (50 μl/paw) at 2 weeks. (A and C) Paw edema analyzed in a plesthysmometer (difference between the right and the left paws), and (B and D) immobility time in tail suspension test (TST). Effect of treatment with imipramine, fluoxetine and bupropion (10 mg/kg, 20 mg/kgand 30 mg/kg, p.o, once a day, 7 days; respectively) or dexamethasone, indomethacin and celecoxib (0.5 mg/kg, s.c., 10 mg/kg, p.o. and 30 mg/kg, p.o., once a day, for 7 days, respectively). Independent groups were used to analyse the effects of anti-inflammatory or antidepressant drugs on paw edema or depression-like behavior. Each column represents mean ± SEM of 6-8 animals per group. *P < 0.05 and **P < 0.01 significantly different from Saline+Saline group; # P < 0.05 and # # P < 0.01 significantly different from CFA+Saline group (ANOVA followed by Bonferroni’s post-hoc test).