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. 2013 Sep 27;8(9):e77227. doi: 10.1371/journal.pone.0077227

Figure 6. Determination of IL-1β, and BDNF levels in the brain of CFA-treated mice: effects of treatment with bupropion and celecoxib.

Figure 6

Effect of intraplantar injection of CFA (50 μl/paw) at 2 weeks: IL-1β levels in the (A) whole brain, (B) cortex and (C) hippocampus. Effect of treatment with celecoxib and bupropion both at (30 mg/kg, p.o, once a day, 7 days) and combined effect of bupropion plus celecoxib (3 mg/kg, p.o, once a day, 7 days). (D) BDNF levels in cortex. Effects of treatment with celecoxib and bupropion (both at 30 mg/kg, p.o, once a day, 7 days) and combination of bupropion and celecoxib (both at 3 mg/kg, p.o, once a day, 7 days). Each column represents the mean ± SEM of 4 animals per group. **P < 0.01 significantly different from Saline+Saline group, # P < 0.05 and # # P < 0.01 significantly different from CFA+Saline group (ANOVA followed by Bonferroni’s post-hoc test).