Table 3. Drugs associated with human gene targets commonly associated withStreptococcus pneumoniae and Pseudomonas aeruginosa infections.
| Gene symbol1 | Number of Drugs2 | Blood-related drug3 | Indications |
|---|---|---|---|
| JUN | 3 | ||
| FOS | 1 | Nadroparin | Anticoagulant |
| ICAM1 | 2 | ||
| IFNGR1 | 1 | ||
| IL1Β | 3 | ||
| ITGB3 | 4 | Abciximab | Anticoagulant |
| Eptifibatide | Anticoagulant | ||
| Tirofiban | Fibrinolytic | ||
| PLAUR | 5 | Alteplase | Thrombolytics |
| PTGS2 | 46 | Acetylsalicylic acid | Thrombolytics |
| SERPINE1 | 6 | Anistreplase | Thrombolytics; Anticoagulant |
| Reteplase | Thrombolytics | ||
| Tenecteplase | Thrombolytics | ||
| Urokinase | Thrombolytics | ||
| Drotrecogin alfa | Anti-sepsis | ||
| TGFB1 | 1 | ||
| VEGFA | 6 | Dalteparin | Thrombolytics |
1 Genes were significant for at least one dataset for both Streptococcus pneumoniae and Pseudomonas aeruginosa.
2 Based on DrugBank searches for approved and non-nutraceuticals drugs.
3 Based on DrugBank categories.