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Pedigrees of families from Guam with SMC dysplasia. Blackened symbols indicate affected individuals, and vertical bars indicate the haplotypes from the linked region on chromosome 18q that segregate with the disease. A, Family SMC1. The recombination interval was defined by recombination events observed for II-5 and II-6. Shaded areas indicate region of autozygosity. B, Family SMC2. The maternal disease haplotype is identical in the two families between markers D18S486 and D18S474.
