Table 1. Gene sets enriched in the response to hypoxic seizures.
| Gene set name | Source | ku | kd | P-value | FDR | cLeft | cRight |
| ion_channels | NC | 245 | 0 | 2.2E-04 | 9.3E-04 | 1.52 | 1 |
| autism_OMIM_jst_manual_curation_2010 | NC | 49 | 0 | 3.2E-03 | 5.6E-03 | 2.08 | 1 |
| PI3K-AKT_Signaling_Pathway_SA | NC | 93 | 0 | 0 | 0 | 1.94 | 1 |
| epilepsy_E18_series4_4AP_8h_CRC_feb_2009 | NC | 253 | 264 | 0 | 0 | 1.68 | 1.43 |
| glutamatergic | NC | 37 | 0 | 4.2E-04 | 1.2E-03 | 4.76 | 1 |
| synapse | NC | 86 | 0 | 3.3E-03 | 5.2E-03 | 1.67 | 1 |
| epilepsy_E18_series4_BIC_8h_CRC_feb_2009 | NC | 332 | 343 | 0.0E+00 | 0.0E+00 | 2.05 | 1 |
| neuron_cahoy_emery_kaushal_2008 | NC | 196 | 0 | 7.5E-03 | 8.9E-03 | 1.72 | 1 |
| axonal_guidance | NC | 57 | 0 | 1.3E-03 | 2.7E-03 | 2.58 | 1 |
| Insulin_Signaling_Pathway_SA | NC | 91 | 0 | 2.4E-02 | 2.4E-02 | 1.51 | 1 |
| IGF_insulin_axis_JST | NC | 13 | 0 | 1.6E-02 | 1.7E-02 | 3.89 | 1 |
| KEGG_WNT_SIGNALING_PATHWAY | BC | 110 | 0 | 0 | 0 | 2.64 | 1 |
| BIOCARTA_NO1_PATHWAY | BC | 26 | 0 | 3.9E-03 | 5.7E-03 | 3.49 | 1 |
| BIOCARTA_CTCF_PATHWAY | BC | 19 | 0 | 3.3E-03 | 5.0E-03 | 4.54 | 1 |
| KEGG_LONG_TERM_DEPRESSION | BC | 57 | 0 | 2.3E-03 | 4.1E-03 | 2.26 | 1 |
| BIOCARTA_CREB_PATHWAY | BC | 24 | 0 | 1.0E-03 | 2.4E-03 | 3.85 | 1 |
| BILD_CTNNB1_ONCOGENIC_SIGNATURE | BC | 39 | 0 | 2.2E-04 | 8.4E-04 | 4.63 | 1 |
| SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES | BC | 55 | 0 | 5.8E-04 | 1.6E-03 | 2.38 | 1 |
| REACTOME_TRANSMISSION_ACROSS_CHEMICAL_ SYNAPSES | BC | 108 | 0 | 4.0E-04 | 1.3E-03 | 2.12 | 1 |
| REACTOME_NEURORANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL | BC | 68 | 0 | 1.1E-03 | 2.4E-03 | 2.12 | 1 |
| REACTOME_POST_NMDA_RECEPTOR_ACTIVATION_EVENTS | BC | 28 | 0 | 3.3E-03 | 5.4E-03 | 3.15 | 1 |
| REACTOME_ACTIVATION_OF_NMDA_RECEPTOR_UPON_GLUTAMATE_BINDING_AND_POSTSYNAPTIC_EVENTS | BC | 32 | 0 | 6.0E-05 | 3.8E-04 | 6.72 | 1 |
| ST_GRANULE_CELL_SURVIVAL_PATHWAY | BC | 21 | 0 | 9.6E-04 | 2.4E-03 | 2.61 | 1 |
| RESPONSE_TO_HYPOXIA | BGO | 25 | 0 | 6.7E-03 | 8.5E-03 | 2.15 | 1 |
| GLUTAMATE_RECEPTOR_ACTIVITY | BGO | 20 | 0 | 7.8E-03 | 9.0E-03 | 4.52 | 1 |
| METABOTROPIC_GLUTAMATEGABA_B_LIKE_RECEPTOR_ACTIVITY | BGO | 10 | 0 | 8.7E-03 | 9.4E-03 | 4.52 | 1 |
| CYCLIC_NUCLEOTIDE_PHOSPHODIESTERASE_ACTIVITY | BGO | 12 | 0 | 1.2E-02 | 1.3E-02 | 3.32 | 1 |
| EGR2_mutations_in_inherited_neuropathies_dominant-negatively_inhibit_m_pubMED_11394999 | PM | 79 | 0 | 4.2E-03 | 5.9E-03 | 2.44 | 1 |
| Signal_transduction_pathways_that_regulate_eukaryotic_protein_synthesi_pubMED_10521405 | PM | 77 | 0 | 5.3E-03 | 6.9E-03 | 2.13 | 1 |
| Proteomic_analysis_of_NMDA_receptor-adhesion_protein_signaling_complex_pubMED_10862698 | PM | 65 | 0 | 0 | 0 | 3.67 | 1 |
| Regulation_of_translation_initiation_by_FRAP/mTOR._pubMED_11297505 | PM | 20 | 0 | 8.4E-03 | 9.4E-03 | 2.78 | 1 |
| Ribosomal_S6_kinase_signaling_and_the_control_of_translation._pubMED_10579915 | PM | 21 | 0 | 1.0E-04 | 5.4E-04 | 2.76 | 1 |
| Mechanism_and_function_of_signal_transduction_by_the_Wnt/beta-catenin__pubMED_10630639 | PM | 30 | 0 | 6.9E-03 | 8.4E-03 | 3.58 | 1 |
| Translation_initiation:_adept_at_adapting._pubMED_10500305 | PM | 25 | 0 | 5.2E-03 | 7.1E-03 | 2.78 | 1 |
| APC,_signal_transduction_and_genetic_instability_in_colorectal_cancer._pubMED_11900252 | PM | 19 | 0 | 1.4E-03 | 2.7E-03 | 4.95 | 1 |
| The_subcellular_destinations_of_APC_proteins._pubMED_11988767 | PM | 27 | 0 | 1.4E-04 | 6.7E-04 | 2.55 | 1 |
| Protein_trafficking_and_anchoring_complexes_revealed_by_proteomic_anal_pubMED_15024025 | PM | 13 | 0 | 1.2E-03 | 2.5E-03 | 2.16 | 1 |
The table displays the 37 gene sets out of an initial set of 6,394 which scored significant enrichment against the 12 hour hippocampal response to hypoxic seizures. The gene sets originated from five distinct collections (see Methods), with the source indicated in the second column: NC = “neuronal consolidated”, BC = “Broad, curated”, BGO = “Broad, Gene Ontology”, PM = PubMed (no gene sets were selected from the Broad Connectivity Map collection). Keys for column headings: ku = number of positive regulated; kd = number of negative regulatees; the enrichment factors cLeft and cRight refer to slopes of the distribution functions in the KS plots (see Methods). P-values exactly equal to 0 are equivalent to P-value<10−5. A total of 261 leading-edge genes are represented across the selected gene sets.