Table 2. SMR with 95% confidence intervals (95% CI) and absolute risk differences for mortality after hip fracture among PCa men on ADT and PCa men not on ADT.
| PCA ON ADT | PCA NOT ON ADT | |||||||||||||
| RELATIVE RISK | ABSOLUTE RISK | RELATIVE RISK | ABSOLUTE RISKS | |||||||||||
| SMR | 95% CI | Obs/Exp | Absolute risk for men on ADT with hip fracture | Absolute risk for men on ADT | Absolute Risk Difference | 95% CI | SMR | 95% CI | Obs/Exp | Absolute risk for men not on ADT with hip fracture | Absolute risk for men not on ADT | Absolute Risk Difference | 95% CI | |
| Overall | 2.44 | (2.29–2.60) | 940/385.3 | 50.8 | 20.8 | 30.0 | (26.7–33.2) | 2.97 | (2.66–3.30) | 344/115.8 | 29.5 | 9.9 | 19.6 | (16.5–22.7) |
| Stratified by time since hip fracture | ||||||||||||||
| 0-1 months | 7.15 | (6.14–8.27) | 180/25.2 | 153.5 | 21.5 | 132.0 | (109.6–154.4) | 12.5 | (9.78–15.6) | 74/5.9 | 122.7 | 9.9 | 112.8 | (84.9–140.8) |
| 1-3 months | 3.30 | (2.86–3.78) | 205/62.2 | 69.8 | 21.2 | 48.6 | (39.0–58.1) | 4.76 | (3.73–6.00) | 72/15.1 | 45.4 | 9.5 | 35.8 | (25.4–46.3) |
| 3-12 months | 2.03 | (1.79–2.31) | 243/119.5 | 42.8 | 21.0 | 21.7 | (16.3–27.1) | 2.49 | (1.97–3.10) | 80/32.1 | 23.8 | 9.5 | 14.2 | (9.0–19.4) |
| 1-2 years | 1.85 | (1.60–2.13) | 192/103.7 | 38.4 | 20.7 | 17.7 | (12.2–23.1) | 1.92 | (1.47–2.46) | 61/31.8 | 19.0 | 9.9 | 9.1 | (4.3–13.8) |
| 2+ years | 1.61 | (1.33–1.92) | 120/74.7 | 32.4 | 20.1 | 12.2 | (6.4–18.0) | 1.85 | (1.40–2.39) | 57/30.8 | 19.8 | 10.7 | 9.1 | (3.9–14.2) |
| Stratified by CCI | ||||||||||||||
| 0 | 2.13 | (1.89–2.39) | 289/135.4 | 43.1 | 20.2 | 22.9 | (17.9–27.9) | 1.72 | (1.35–2.15) | 76/44.3 | 16.5 | 9.6 | 6.9 | (3.2–10.6) |
| 1 | 2.29 | (2.01–2.61) | 229/99.9 | 48.0 | 20.9 | 27.1 | (20.8–33.3) | 2.72 | (2.15–3.39) | 78/28.7 | 26.8 | 9.9 | 16.9 | (11.0–22.8) |
| 2 | 2.76 | (2.38–3.19) | 190/68.7 | 55.4 | 20.0 | 35.4 | (27.5–43.2) | 3.51 | (2.73–4.44) | 69/19.7 | 37.2 | 10.6 | 26.6 | (17.8–35.4) |
| 3+ | 2.86 | (2.50–3.25) | 232/81.2 | 64.4 | 22.5 | 41.9 | (33.6–50.2) | 5.22 | (4.33–6.23) | 121/23.2 | 53.1 | 10.2 | 42.9 | (33.5–52.4) |
| Time since hip fracture for men with CCI = 0 | ||||||||||||||
| 0-1 months | 5.64 | (4.16–7.48) | 48/8.5 | 121.0 | 21.5 | 99.6 | (65.3–133.8) | 5.53 | (2.76–9.89) | 11/2.0 | 53.5 | 9.7 | 43.9 | (12.2–75.5) |
| 1-3 months | 2.72 | (2.06–3.51) | 58/21.4 | 56.5 | 20.8 | 35.7 | (21.2–50.3) | 3.88 | (2.37–5.99) | 20/5.2 | 35.7 | 9.2 | 26.5 | (10.9–42.2) |
| 3-12 months | 1.93 | (1.54–2.40) | 81/41.9 | 40.1 | 20.7 | 19.4 | (10.6–28.1) | 1.78 | (1.08–2.74) | 20/11.3 | 16.2 | 9.1 | 7.1 | (-0.0–14.2) |
| 1-2 years | 1.67 | (1.29–2.14) | 64/38.2 | 34.2 | 20.4 | 13.8 | (5.4–22.2) | 1.03 | (0.53–1.80) | 12/11.6 | 9.3 | 9.0 | 0.3 | (-5.0–5.5) |
| 2+ years | 1.49 | (1.06–2.05) | 38/25.5 | 27.4 | 18.4 | 9.0 | (0.3–17.7) | 0.91 | (0.49–1.56) | 13/14.2 | 9.8 | 10.7 | -0.9 | (-6.2–4.4) |
| Time since hip fracture for men with CCI > 0 | ||||||||||||||
| 0-1 months | 7.91 | (6.62–9.38) | 132/16.7 | 170.0 | 21.5 | 148.5 | (119.5–177.5) | 15.93 | (12.2–20.4) | 63/4.0 | 158.4 | 9.9 | 148.4 | (109.3–187.6) |
| 1-3 months | 3.60 | (3.04–4.23) | 147/40.8 | 76.9 | 21.4 | 55.5 | (43.1–67.9) | 5.22 | (3.90–6.85) | 52/10.0 | 50.6 | 9.7 | 40.9 | (27.2–54.7) |
| 3-12 months | 2.09 | (1.78–2.43) | 162/77.7 | 44.2 | 21.2 | 23.0 | (16.2–29.8) | 2.88 | (2.19–3.70) | 60/20.9 | 28.1 | 9.8 | 18.3 | (11.2–25.4) |
| 1-2 years | 1.96 | (1.63–2.33) | 128/65.5 | 40.9 | 20.9 | 20.0 | (12.9–27.1) | 2.43 | (1.80–3.21) | 49/20.2 | 25.4 | 10.4 | 14.9 | (7.8–22.1) |
| 2+ years | 1.67 | (1.33–2.07) | 82/49.2 | 35.3 | 21.2 | 14.1 | (6.5–21.8) | 2.65 | (1.92–3.55) | 44/16.6 | 28.3 | 10.7 | 17.6 | (9.2–26.0) |
The background population for these calculations were all men with PCa in PCBaSe Sweden (Red arrows in Figure 1). The SMRs were calculated by dividing the observed number of events (obs) by the expected number of events (exp).