Table 1. Demographic and clinicopathological data of Ovarian Cancer samples (Training set and independent validation set) and Normal Ovarian samples.
1st portion of Cases (n = 33) | 2nd portion of cases (n = 24) | Training set (Total) | Controls(n = 13) | |
Age at diagnosis | ||||
Median | 57 | 56 | 57 | 46 |
Range | 23–79 | 37–77 | 23–77 | 40–55 |
Follow-up (months) | ||||
Median | 24 | 37 | 30.5 | |
Range | 0–228 | 13–79 | 0–228 | |
Race | ||||
Caucasian | 24 | 24 | 48 | 0 |
African-american | 8 | 0 | 8 | 0 |
Hispanic | 0 | 0 | 0 | 13 |
Unknown | 1 | 0 | 1 | 0 |
Tumor type | ||||
EOC* | 33 | 18 | 51 | |
Germ cell tumor | 0 | 1 | 1 | |
Metastasis | 0 | 4 | 4 | |
Unknown | 0 | 1 | 1 | |
Histology | ||||
Serous-papillary | 33 | 11 | 44 | |
Endometrioid | 0 | 4 | 4 | |
Mucinous | 0 | 2 | 2 | |
Undifferentiated | 0 | 1 | 1 | |
Unknown | 0 | 6 | 6 | |
Stage | ||||
I | 15 | 6 | 21 | |
II | 1 | 4 | 5 | |
III | 14 | 12 | 26 | |
IV | 3 | 1 | 4 | |
Unknown | 0 | 1 | 1 | |
Grade | ||||
Borderline | 12 | 0 | 12 | |
G1 | 0 | 2 | 2 | |
G2 | 8 | 5 | 13 | |
G3 | 13 | 12 | 25 | |
GX** | 0 | 1 | 1 | |
Unknown | 0 | 4 | 4 | |
Chemotherapy | ||||
Yes | 11 | 23 | 34 | |
No | 9 | 0 | 9 | |
Unknown | 13 | 1 | 14 | |
Type of chemotherapy | ||||
Platinum/taxol after surgery | 0 | 18 | 18 | |
Platinum/taxol before and after surgery | 0 | 6 | 6 | |
Unknown | 33 | 0 | 33 | |
Recurrence | ||||
Yes | 4 | 14 | 18 | |
No | 0 | 10 | 10 | |
Unknown | 29 | 0 | 29 | |
Metastasis | ||||
Yes | 1 | 0 | 1 | |
No | 32 | 0 | 32 | |
Unknown | 0 | 24 | 24 | |
Smoking | ||||
Smoker | 2 | 5 | 7 | |
Non-smoker | 16 | 19 | 35 | |
Unknown | 15 | 0 | 15 | |
Alcohol | ||||
Current | 6 | 2 | 8 | |
No | 12 | 22 | 34 | |
Unknown | 15 | 0 | 15 | |
B. Validation set | ||||
Ovarian cancer patients n = 372 | ||||
Age at diagnosis | ||||
Median | 61 | |||
Range | 21–89 | |||
Follow-up time (months) | ||||
Median | 30 | |||
Range | 0–234 | |||
Unknown n = 1 | ||||
Histology | n | % | ||
Serous | 227 | 61% | ||
Mucinous | 43 | 12% | ||
Endometroid | 39 | 10% | ||
Clear cell | 18 | 5% | ||
Adenocarcinoma | 13 | 3% | ||
Other | 31 | 8% | ||
Unknown | 1 | 0% | ||
Grade | ||||
Borderline | 5 | 1% | ||
I | 57 | 15% | ||
II | 101 | 27% | ||
III | 154 | 41% | ||
Undifferentiated | 19 | 5% | ||
Unknown | 36 | 10% | ||
FIGO Stage | ||||
I | 67 | 18% | ||
II | 30 | 8% | ||
III | 224 | 60% | ||
IV | 51 | 14% | ||
Residual disease after surgery | ||||
<2 cm | 184 | 49% | ||
>2 cm | 160 | 43% | ||
Unknown | 28 | 8% | ||
Chemotherapy | ||||
No chemotherapy | 56 | 15% | ||
Platinum-containing | 173 | 47% | ||
Platinum and taxane containing | 105 | 28% | ||
Other | 30 | 8% | ||
Unknown | 8 | 2% | ||
316 | ||||
Borderline tumors n = 17 | ||||
Age at diagnosis | ||||
Median | 50 | |||
Range | 19–77 | |||
Unknown (n = 5) | ||||
Cystadenoma n = 18 | ||||
Age at diagnosis | ||||
Median | 30 | |||
Range | 26–55 | |||
Unknown (n = 15) |
Epithelial ovarian cancer ** Grade cannot be assessed.