Table 1. Pathway Analysis of K7174-regulated genes.
MAPP Name | N | Z Score | |
---|---|---|---|
(Upregulated) | Senescence_and_Autophagy | 13 | 4.57 |
Phosphatidylinositol_signaling_system | 11 | 3.84 | |
Folate | 8 | 3.81 | |
Keap1-Nrf2 | 3 | 3.5 | |
MAPK_signaling_pathway | 12 | 3.3 | |
Selenium | 7 | 2.93 | |
Glutathione_metabolism | 3 | 2.89 | |
Glycine_serine_and_threonine_metabolism | 5 | 2.78 | |
Adipogenesis | 10 | 2.7 | |
Cysteine_metabolism | 2 | 2.36 | |
Keratan_sulfate_biosynthesis | 2 | 2.36 | |
Ganglioside_biosynthesis | 2 | 2.36 | |
Insulin_Signaling | 11 | 2.35 | |
Glutamate_metabolism | 4 | 2.32 | |
TGF_Beta_Signaling_Pathway | 5 | 2.32 | |
Type_II_interferon_signaling_(IFNG) | 3 | 2.25 | |
Regulation_of_Actin_Cytoskeleton | 9 | 2.21 | |
Nuclear_receptors_in_lipid_metabolism_and_toxicity | 3 | 2.09 | |
Nitrogen_metabolism | 2 | 2.08 | |
(Downregulated) | DNA_Replication | 16 | 7.45 |
G1_to_S_cell_cycle_control | 15 | 5.04 | |
Electron_Transport_Chain | 20 | 4.61 | |
Oxidative_phosphorylation | 14 | 4.45 | |
Mismatch_repair | 4 | 4.09 | |
Cell_cycle | 15 | 3.96 | |
Urea_cycle_and_metabolism_of_amino_groups | 6 | 3.8 | |
beta_Alanine_metabolism | 5 | 3.59 | |
Folate | 9 | 3.46 | |
Fatty_acid_metabolism | 9 | 3.35 | |
Arginine_and_proline_metabolism | 9 | 3.24 | |
D_Glutamine_and_D_glutamate_metabolism | 2 | 3.22 | |
Methane_metabolism | 3 | 3.21 | |
Nucleotide_Metabolism | 5 | 3.14 | |
Urea_cycle_and_metabolism_of_amino_groups | 5 | 3.14 | |
Lysine_degradation | 8 | 2.98 | |
One_carbon_pool_by_folate | 4 | 2.86 | |
Fatty_acid_biosynthesis_path_2 | 4 | 2.86 | |
Nitrogen_metabolism | 3 | 2.84 | |
Selenium | 8 | 2.66 | |
Tryptophan_metabolism | 9 | 2.66 | |
Statin_Pathway_PharmGKB | 5 | 2.61 | |
Butanoate_metabolism | 6 | 2.51 | |
One_Carbon_Metabolism | 5 | 2.46 | |
Histidine_metabolism | 6 | 2.39 | |
Bile_acid_biosynthesis | 5 | 2.31 | |
Ascorbate_and_aldarate_metabolism | 3 | 2.28 | |
Propanoate_metabolism | 5 | 2.18 | |
Ubiquinone_biosynthesis | 9 | 2.17 | |
Glutathione_metabolism | 4 | 2.1 | |
Glycolysis_Gluconeogenesis | 6 | 2.06 | |
Glycine_serine_and_threonine_metabolism | 5 | 2.05 |
Genes showing > 2 fold differences after K7174 treatment in HepG2 cells were analyzed with GenMAPP ver.2.1 (MAPP Finder).