Table 1. Pathway Analysis of K7174-regulated genes.

	MAPP Name	N	Z Score
(Upregulated)	Senescence_and_Autophagy	13	4.57
	Phosphatidylinositol_signaling_system	11	3.84
	Folate	8	3.81
	Keap1-Nrf2	3	3.5
	MAPK_signaling_pathway	12	3.3
	Selenium	7	2.93
	Glutathione_metabolism	3	2.89
	Glycine_serine_and_threonine_metabolism	5	2.78
	Adipogenesis	10	2.7
	Cysteine_metabolism	2	2.36
	Keratan_sulfate_biosynthesis	2	2.36
	Ganglioside_biosynthesis	2	2.36
	Insulin_Signaling	11	2.35
	Glutamate_metabolism	4	2.32
	TGF_Beta_Signaling_Pathway	5	2.32
	Type_II_interferon_signaling_(IFNG)	3	2.25
	Regulation_of_Actin_Cytoskeleton	9	2.21
	Nuclear_receptors_in_lipid_metabolism_and_toxicity	3	2.09
	Nitrogen_metabolism	2	2.08
(Downregulated)	DNA_Replication	16	7.45
	G1_to_S_cell_cycle_control	15	5.04
	Electron_Transport_Chain	20	4.61
	Oxidative_phosphorylation	14	4.45
	Mismatch_repair	4	4.09
	Cell_cycle	15	3.96
	Urea_cycle_and_metabolism_of_amino_groups	6	3.8
	beta_Alanine_metabolism	5	3.59
	Folate	9	3.46
	Fatty_acid_metabolism	9	3.35
	Arginine_and_proline_metabolism	9	3.24
	D_Glutamine_and_D_glutamate_metabolism	2	3.22
	Methane_metabolism	3	3.21
	Nucleotide_Metabolism	5	3.14
	Urea_cycle_and_metabolism_of_amino_groups	5	3.14
	Lysine_degradation	8	2.98
	One_carbon_pool_by_folate	4	2.86
	Fatty_acid_biosynthesis_path_2	4	2.86
	Nitrogen_metabolism	3	2.84
	Selenium	8	2.66
	Tryptophan_metabolism	9	2.66
	Statin_Pathway_PharmGKB	5	2.61
	Butanoate_metabolism	6	2.51
	One_Carbon_Metabolism	5	2.46
	Histidine_metabolism	6	2.39
	Bile_acid_biosynthesis	5	2.31
	Ascorbate_and_aldarate_metabolism	3	2.28
	Propanoate_metabolism	5	2.18
	Ubiquinone_biosynthesis	9	2.17
	Glutathione_metabolism	4	2.1
	Glycolysis_Gluconeogenesis	6	2.06
	Glycine_serine_and_threonine_metabolism	5	2.05

Genes showing > 2 fold differences after K7174 treatment in HepG2 cells were analyzed with GenMAPP ver.2.1 (MAPP Finder).