Table 1.
Frequency of the SPINK1 N34S Variant in the Various Study Groups
|
SPINK1 Genotype Frequency (n) |
||||
| Group (n) | HomozygoteWild-Type | HeterozygoteN34S | HomozygoteN34S | P Valuea |
| Bangladeshi: | ||||
| Probands with FCPD (69) | .739 (51) | .217 (15) | .043 (3) | <.0001 |
| Other FCPD (43) | .581 (25) | .279 (12) | .140 (6) | <.0001 |
| Nondiabeticb (393) | .944 (371) | .053 (21) | .003 (1) | |
| Under-30 diabetes (354) | .893 (316) | .099 (35) | .008 (3) | .02 |
| Sylheti Nondiabeticc (156) | .968 (151) | .032 (5) | 0 | |
| Sylheti T2D (142) | .965 (137) | .035 (5) | 0 | NS |
| South Indian: | ||||
| FCPD (68) | .647 (44) | .265 (18) | .088 (6) | <.0001 |
| Nondiabetic (312)b | .965 (301) | .032 (10) | .003 (1) | |
| Impaired fasting glucose/IGT (56) | .964 (54) | .036 (2) | 0 | NS |
| T2D (77) | .961 (74) | .039 (3) | 0 | NS |
a
For comparison with nondiabetic group. NS = not significant.
b
Defined by fasting blood glucose <6 mmol/liter.
c
Defined by either a random or fasting blood glucose <6 mmol/liter.