Table 5. Volumetric brain measurements in patients with CPEO harbouring single and multiple mtDNA deletions.
| Genetic group | Grey matter | White matter | Brainstem | Cerebellum |
| Mean ± SD (cm3) (%)a | Mean ± SD (cm3) (%)a | Mean ± SD (cm3) (%)a | Mean ± SD (cm3) (%)a | |
| Single mtDNA deletion (n = 9) | 594.2±9.6 (6.6%) | 437.9±14.2 (7.9%) | 28.2±0.8 (7.2%) | 112.6±3.9 (10.8%) |
| P = 0.0402 | P = 0.1168 | P = 0.0575 | P = 0.0094 | |
| Multiple mtDNA deletions (n = 11) | 572.3±22.7 (10.1%) | 462.8±20.7 (2.6%) | 28.1±1.1 (7.6%) | 111.0±4.0 (12.1%) |
| P = 0.0344 | P = 0.6516 | P = 0.1012 | P = 0.0061 | |
| Controls (n = 10) | 636.5±15.8 | 475.3±17.3 | 30.4±0.6 | 126.3±2.7 |
a
Percentage reduction compared with controls. The respective P values indicate the level of significance for the comparisons with the control data set. SD = standard deviation.