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. Author manuscript; available in PMC: 2014 Sep 4.
Published in final edited form as: J Am Chem Soc. 2013 Aug 22;135(35):12924–12927. doi: 10.1021/ja403007r

Figure 1.

Figure 1

Structure of wild-type E. coli DHFR structure (PBD 1RA1), showing Glu17 in green and Ile115 in blue. The amino acid residue (Met16) which is close spatially to the side chain of Glu17 (≤ 4 Å) is shown in red. The amino acid residues (Ala7, Trp22, Leu24, Thr113 and Ala117) which are close to the side chain of Ile115 (≤ 4 Å) are shown in magenta.