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Effect of the DHFR inhibitor trimethoprim on the fluorescence emission spectrum of 0.5 µM modified DHFR II containing L-(7-hydroxycoumarin-4-yl)ethylglycine (2) at position 17 and biphenyl-phenylalanine (1) at position 115 following excitation at 280 nm. The red line is the emission spectrum of modified DHFR II alone; the blue, purple and green lines reflect the effect of 2, 4 and 6 µM trimethoprim (TMP), respectively, on the emission spectrum of the modified DHFR.
