Table 1.
Experimental groups and testing sequence
| Group | n | Treatment (mg/kg) | Age | Interval 1 | Test 1 | Interval 2 | Test 2 |
|---|---|---|---|---|---|---|---|
| 1 (Fig. 1) | 8 | 1 day Ketamine (0, 5, 10, 20) | Adolescent | 24 h | FST | - | - |
| 2 (Fig. 2) | 8–12 | CUS + single injection ketamine (0, 20) | Adolescent | 1 h | FST | - | - |
| 3 (Fig. 3) | 19–20 | Single Injection ketamine (0, 20) | Adolescent | - | Locomotion | - | - |
| 4 (Fig 3) | 19–20 | Single Injection ketamine (0, 20) | Adult | - | Locomotion | - | - |
| 5 (Fig. 4, 5, S2) | 10 | 15 days Ketamine (0, 20; BID) | Adolescent | 2 months | Locomotion | 48 h | EPM |
| 6 (Fig. 4, 5, S2) | 10 | 15 days Ketamine (0, 20; BID) | Adult | 2 months | Locomotion | 48 h | EPM |
| 7 (Fig. 5, S2) | 9–10 | 1 day Ketamine (0, 20; BID) | Adolescent | 2 months | Locomotion | 48 h | EPM |
| 8 (Fig. 5, S2) | 10 | 1 day Ketamine (0, 20 BID) | Adult | 2 months | Locomotion | 48 h | EPM |
| 9 (Fig. S1) | 9–10 | Single Injection ketamine (0, 20) | Adolescent | 1 h | Locomotion | - | - |
| 10 (Fig. S3) | 10 | 1 day Ketamine (0, 20; BID) | Adolescent | 2 months | SP* | 48 h | FST |
| 11 (Fig. S3) | 10 | 1 day Ketamine (0, 20; BID) | Adult | 2 months | SP* | 48 h | FST |
| 12 (Fig. 6, S4) | 12 | 15 days Ketamine (0, 20; BID) | Adolescent | 2 months | SP | 48 h | FST |
| 13 (Fig. 6, S4) | 11–12 | 15 days Ketamine (0, 20; BID) | Adult | 2 months | SP | 48 h | FST |
| 14 (Fig. 6) | 6–10 | Ketamine (0, 5,10, 20) | Adolescent | - | CPP | - | - |
Injections intraperitoneal; BID, twice daily; EPM, elevated plus maze; FST, forced swimming test; SP, sucrose preference; CPP, Conditioned Place Preference; S, Supplemental
*
Data not shown