Table 1.
Case-controls studies investigating the association of non-steroidal anti-inflammatory drugs, steroids, opioids, calcium channel blockers and perforated diverticular disease
| Author | Country | Drugs | Patients (n) | Control group (n) | OR |
| Goh et al[20] | United Kingdom | NSAIDs | 20 | HC (600), DD (125) | 2.1 (95%CI: 1.3-3.4) for HC |
| 4.6 (95%CI: 1.7-12.5) for DD | |||||
| Mpofu et al[25] | United Kingdom | NSAIDs | 64 | HC (320) | 1.8 (95%CI: 0.96-3.4) |
| Corder et al[26] | United Kingdom | NSAIDs | - | DD | 4.8 (95%CI: 1.6-14.8) |
| Humes et al[27] | United Kingdom | NSAIDs | 899 | HC (8980) | 1.5 (95%CI: 1.01-2.3) |
| Piekarek et al[28] | Sweden | NSAIDs | 54 | DD (183) | 3.6 (95%CI: 1.5-8.4) |
| Mpofu et al[25] | United Kingdom | Steroids | 64 | HC (320) | 31.9 (95%CI: 6.4-159.2) |
| Corder et al[26] | United Kingdom | Steroids | - | DD | 13.2 (95%CI: 1.81-96.5) |
| Humes et al[27] | United Kingdom | Steroids | 899 | HC (8980) | 2.7 (95%CI: 1.6-4.6) |
| Piekarek et al[28] | Sweden | Steroids | 54 | DD (183) | 28.3 (95%CI: 4.8-165.7) |
| Humes et al[27] | United Kingdom | Opioids | 899 | HC (8980) | 2.2 (95%CI: 1.6-3.0) |
| Piekarek et al[28] | Sweden | Opioids | 54 | DD (183) | 4.5 (95%CI: 1.7-12.2) |
| Morris et al[3] | United Kingdom | Ca2+ | 120 | HC (480) | 0.4 (95%CI: 0.2-0.9) |
| Humes et al[27] | United Kingdom | Ca2+ | 899 | HC (8980) | 0.54 (95%CI: 0.24-1.24) |
| Piekarek et al[28] | Sweden | Ca2+ | 54 | DD (183) | 0.14 (95%CI: 0.02-0.95) |
NSAIDs: Non-steroidal anti-inflammatory drugs; Ca2+: Calcium-channels blockers; HC: Healthy control; DD: Non-perforated diverticular disease.