Table 1.
Mutant mice with relevance to ADHD discussed in this review
| Mutant mice | Mutation | References |
|---|---|---|
| Dopamine transmission-related genes | ||
| • DAT-KO | Knock-out of dopamine transporter gene | Giros et al. 1996; Gainetdinov and Caron 2000; Trinh et al. 2003 |
| • DAT-KD | Knock-down of dopamine transporter gene | Zhuang et al. 2001; Tilley et al. 2007 |
| • DAT-CI | Triple point-mutation in the cocaine-binding site of DAT | Napolitano et al. 2010; Tilley and Gu 2008a |
| • BAC DAT-tg | Overexpression of dopamine transporter | Salahpour et al. 2008 |
| • D4R-KO | Knock-out of dopamine receptor 4 | Rubinstein et al. 1997; Helms et al. 2008 |
| Other genes | ||
| • NK1R-KO | Knock-out of tachykinin-1 receptor | De Felipe et al. 1998; Yan et al. 2009 |
| • TRβPV-KI | Knock-in of human thyroid hormone β receptor gene | Kaneshige et al. 2000; Siesser et al. 2006 |
| • 39 XyO mice | End-to-end fusion of the X and Y chromosome resulting in steroid sulfatase deficiency | Davies et al. 2007, 2009 |
| • Coloboma mice/SNAP25 (synaptosomal-associated protein 25) mutant mice | Mutation on chromosome 2 with approximately 20 genes disrupted including SNAP-25 | Searle 1966; Bruno et al. 2007 |
| • nAChR β2-KO | Knock-out of β2-subunit of the nicotinic acetylcholine receptor | Granon et al. 2003; Granon and Changeux 2006 |
| • CK1δ mice | Over-expression of the subunit δ of casein kinase1 | Zhou et al. 2010 |
| • Git1-KO | Knock-out of G-protein-coupled receptor kinase-interacting protein-1 | Won et al. 2011; Schmalzigaug et al. 2009 |
| • CdK5-KO | Knock-out of Cdk5-activating cofactor p35 | Drerup et al. 2010 |
| • Gβ5-KO | Knock-out of type 5 G protein beta subunit | Xie et al. 2012 |
| • DGKβ KO | Knock-out of diacylglycerol kinase β | Ishisaka et al. 2012 |