Fig. 1.

Accuracy of contact prediction. Comparison of GREMLIN with DCA (A), PSICOV (B), MIc (C), and GREMLIN when no prior information is used (D). Each point corresponds to a protein, the axes indicate the accuracy of the top ranked L/2 Cβ−Cβ contacts predicted by the indicated methods. (E) (solid lines) Average accuracy for varying numbers of predictions; (broken lines) fraction of targets where GREMLIN was more accurate than the indicated method. Dependence of accuracy of the top L/5 (F) and L/2 (G) predictions on the alignment depth for a subset of 75 targets with deep alignments.