Table 2.
Of1 selectively potentiates β-lactam antibiotics in multidrug-resistant MRSA
| Compound | MIC (µg/mL) | MIC (+Of1)* (µg/mL) | Fold of potentiation | Sensitive range† (µg/mL) |
| Of1 | >128 | — | — | — |
| Methicillin | 128 | 8 | 16 | ≤8 |
| Oxacillin | 64 | 0.5 | 128 | ≤2 |
| Amox/clav | 32/16 | 4/2 | 8 | ≤4/2 |
| Meropenem | 4 | 0.25 | 16 | ≤4 |
| Imipenem | 8 | 1 | 8 | ≤4 |
| Cephalexin | 256 | 16 | 16 | ≤8 |
| Cefazolin | 128 | 4 | 32 | ≤8 |
| Rifampicin | 2 | 1 | 2 | ≤1 |
| Tetracycline | 64 | 64 | 1 | ≤4 |
| Ciprofloxacin | 8 | 8 | 1 | ≤1 |
| Azithromycin | >256 | >256 | — | ≤2 |
| Erythromycin | >256 | >256 | — | ≤0.5 |
| Clindamycin | >256 | >256 | — | ≤0.5 |
| Streptomycin | >256 | >256 | — | — |
| Vancomycin | 1 | 1 | 1 | ≤2 |
| Linezolid | 2 | 2 | 1 | ≤4 |
*
MIC value in the presence of 20 µM Of1.
†
Values obtained from Clinical Laboratory Standards Institute (CLSI) Performance Standards for Antimicrobial Testing; 17th informational supplement (36).