Fig. 1.
Effect of H2S on platelet aggregation induced by TRAP-6. (A) Both NaHS and l-Cys induced significant concentration-dependent increase in TRAP-6-induced platelet aggregation (**P < 0.01 for NaHS 1 µM, ***P < 0.001 for NaHS 10 µM and 100 µM; °P < 0.05 for l-Cys 10 µM, °°°P < 0.001 for l-Cys 100 µM). d-Cys did not affect platelet aggregation induced by TRAP-6. (B) The effect of l-Cys was significantly inhibited by both AOAA (1 mM; **P < 0.05) and PAG (10 mM; °°P < 0.05). Results are expressed as percent of maximal aggregation and calculated as mean ± SEM from 15 healthy volunteers. Data were analyzed using one-way ANOVA followed by Bonferroni post-test.