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. 2013 Sep 9;110(39):15812–15817. doi: 10.1073/pnas.1309049110

Fig. 2.

Fig. 2.

Measurement of cAMP levels in human washed platelet. PGI2 caused a significant increase in cAMP level compared with vehicle (°°°P < 0.001) in platelets harvested from healthy volunteers. TRAP-6 (2 µM) significantly inhibited PGI2-induced cAMP production (**P < 0.01). NaHS (100 µM), l-Cys (100 µM), and d-Cys (100 µM) did not modify cAMP levels compared with TRAP-6. Results are expressed as nM and calculated as mean ± SEM from five healthy volunteers. Data were analyzed using one-way ANOVA followed by Bonferroni post-test.