Fig. 7.

The effect of H₂S upon human platelet TXB₂ levels. NaHS (100 µM), l-Cys (100 µM), but not d-Cys (100 µM) significantly increased the production of TXB₂ stimulated by TRAP-6 (2 µM; **P < 0.01). Both INDO (1 µM, °°°P < 0.001) and AACOCF₃ (1 µM, ^###P < 0.001) markedly inhibited the effects of both NaHS and l-Cys. NaHS (100 µM) or l-Cys (100 µM) by itself did not affect TXB₂ production. Results are expressed as ng/mL and calculated as mean ± SEM from 10 healthy volunteers. Data were analyzed using one-way ANOVA followed by Bonferroni posttest.