FIG. 4.

Protection elicited by poststress treatment with PNU282987 is associated to the nuclear factor-erythroid-2-related factor 2 (Nrf2)/HO-1 axis. (A) Following the protocol shown in Figure 2A, the protective effect of post-OGD treatment with 10 μM PNU282987 was tested in organotypic slices of Nrf2 wild-type (Nrf2^+/+) and null mice (Nrf2^−/−). Data are mean±SEM of six different experiments; ***p<0.001 compared with the untreated-slices, ##p<0.01 with respect to OGD. (B) shows representative immunoblots of HO-1 induction under the different experimental conditions shown in A.