Figure 3.

Response of fusion kinetics to altered cholesterol levels in influenza virions or target vesicles. Normalized fusion rates are plotted to visualize trends more clearly; these correspond to the unnormalized rates plotted in Figure 2. (A and B) Rates of lipid (A) and contents (B) mixing are plotted as a function of mol % cholesterol in target vesicles. (C and D) Rates of lipid (C) and contents (D) mixing are plotted as a function of the cholesterol/viral protein ratio after cyclodextrin treatment. Significance was assessed via the Kolmogorov-Smirnov test with a Bonferroni multiple-hypothesis correction; ^∗∗ denotes a significant change from both the baseline and the prior condition, p < 0.02. Error bars are plotted as interquartile ranges. Trend lines are placed as visual guides.