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Three large GTPases control mitochondrial morphology in yeast. The predicted domain structures of Fzo1p, Dnm1p and Mgm1p, and their submitochondrial localization patterns are shown here. The known (Fzo1p, Dnm1p) or postulated (Mgm1p) function of each GTPase in mitochondrial membrane dynamics is indicated. The magnified views below the Mgm1p localization diagram show possible roles of Mgm1p in inner membrane fission (left) or cristae formation (right).
