Table 2.

Results of Simulation A. True values of each diagnostic test parameter are compared to estimates from a covariate-augmented LCA model with a variable risk function (“Modell”) and a model that used an age cutoff to divide the population into two groups with different prevalences (“Model2”). Each parameter estimate is presented as mean ± standard deviation (95% CI) of 1000 simulations. All values are reported as percents.

Modell
True	Estimated	True	Estimated	True	Estimated	True	Estimated
S1	S1	C1	C1	S2	S2	C2	C2
70	69 ± 17.4 (40,100)	70	71 ± 2.6 (67,77)	70	69 ± 17.2 (42,100)	70	71 ± 2.5 (67,77)
70	69 ± 7.2 (56,84)	70	70 ± 1.7 (67,74)	95	88 ± 13.6 (57,100)	95	95 ± 1.6 (93,99)
70	71 ± 9.7 (53,92)	95	95 ± 1 (93,97)	70	71 ± 9.8 (53,93)	95	95 ± 1 (93,97)
85	85 ± 10.5 (65,100)	85	85 ± 1.5 (82,88)	85	84 ±10.3 (64,100)	85	85 ± 1.5 (83,88)
85	85 ± 7.1 (71,100)	85	85 ± 1.2 (83,88)	95	93 ± 8.2 (74,100)	95	95 ± 1 (93,97)
85	85 ± 7.5 (71,100)	95	95 ± 0.9 (93,97)	85	85 ± 7.8 (70,100)	95	95 ± 0.9 (93,97)
95	92 ± 8.8 (71,100)	70	71 ± 2 (67,75)	95	91 ± 9.4 (69,100)	70	71 ± 1.9(67,75)
95	93 ± 7.3 (76,100)	85	85 ± 1.4 (83,88)	95	93 ± 7.5 (76,100)	85	85 ± 1.3 (83,88)
95	94 ± 5.3 (82,100)	95	95 ± 0.8 (94,97)	95	94 ± 5.4 (82,100)	95	95 ± 0.8 (94,97)
Model2
70	69 ± 22.3 (37,100)	70	73 ± 7.2 (66,100)	70	68 ± 22.4 (37,100)	70	72 ± 6 (66,95)
70	70 ± 10.1 (53,94)	70	71 ± 2.3 (67,76)	95	82 ± 20 (42,100)	95	95 ± 2.1 (92,100)
70	72 ± 14.6 (48,100)	95	95 ± 1.4 (93,98)	70	72 ± 14.6 (48,100)	95	95 ± 1.4 (93,98)
85	82 ± 15.1 (54,100)	85	86 ± 2.2 (82,91)	85	83 ± 15.1 (53,100)	85	86 ± 2.2 (82,91)
85	84 ± 10.3 (66,100)	85	86 ± 1.7 (83,90)	95	89 ± 12.8 (61,100)	95	95 ± 1.4 (93,98)
85	85 ± 11.2 (64,100)	95	95 ± 1.3 (93,98)	85	85 ± 11.5 (63,100)	95	95 ± 1.2 (93,98)
95	86 ± 14.5 (57,100)	70	72 ± 3.6 (67,80)	95	86 ± 14.9 (56,100)	70	72 ± 3.5 (67,81)
95	89 ± 11.9 (63,100)	85	86 ± 2 (83,90)	95	89 ± 11.5 (65,100)	85	86 ± 2 (83,91)
95	92 ± 8.1 (74,100)	95	95 ± 1.1 (94,98)	95	92 ± 8.1 (75,100)	95	95 ± 1.1 (93,98)