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B-DIM inhibited proteasome activity and induced p27Kip1 expression and PARP cleavage in LNCaP prostate cancer cells. A: LNCaP cells were treated with 50 µM B-DIM for 8–32 h, and proteasomal chymotrypsin-like activity was measured. B: LNCaP cells were treated with 50 µM B-DIM for 8–32 h, followed by Western blot of ubiquitinated proteins. C: LNCaP cells were treated with 50 µM B-DIM for 8–32 h, followed by Western blot of p27Kip1 and PARP.
