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. Author manuscript; available in PMC: 2013 Sep 28.
Published in final edited form as: J Pharmacol Exp Ther. 2008 Jul 29;327(2):442–452. doi: 10.1124/jpet.108.141291

Fig. 1.

Fig. 1

Effect of BG on cisplatin-induced DNA platination in SQ20b head and neck, SKOV-3x ovarian, and A549 nonsmall cell lung cancer cell lines. Cells were treated with 100 μM BG or vehicle followed by 50 μM cisplatin. Cells were collected at various time points after treatment. DNA was analyzed for platinum adducts using atomic absorption spectroscopy. Closed circles, cisplatin treatment alone; closed squares, cisplatin plus BG; closed triangles, cisplatin plus 9-Me-BG. A, SQ20b cell line (cisplatin alone, BG plus cisplatin results previously published in Fishel et al., 2003). B, SKOV-3x cell line. C, A549 cell line. Each point represents the mean ± S.E.M. from at least three experiments. Statistical analysis was performed on normalized samples because of interexperiment variation; *, p < 0.05.