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Toy model of a ligand-gated ion channel. (a) The model ion channel has two binding sites for the control ligand and can exist in four distinct states of occupancy (i.e., empty, 2 × single occupancy, double occupancy) for both the closed and open states. (b) Open probability for a cGMP-gated channel as a function of the cGMP concentration and fit to an MWC model with four binding sites.19
