Fig. 6.

MWC model of nucleosome accessibility. States-and-weights diagram for a toy model of nucleosome accessibility that illustrates how transcription factors could alter the equilibrium of nucleosome-bound DNA. ε_c and ε_o refer to the conformational energies of the closed and open states, respectively, and $K_{\mathrm{d}}^{(\mathrm{C})}$ and $K_{\mathrm{d}}^{(\mathrm{O})}$ are the dissociation constants for transcription factor binding in those two states.