Table 1. Genes represented by the ARS and their correlation with platelet function with aspirin*.
| Affymetrix Probe ID |
Gene Symbol |
Gene Description | Combined PFS beta coefficient * |
Combined P-value |
|---|---|---|---|---|
| Factor 14 | n/a | n/a | −0.76088 | 0.0017 |
| Individual Factor 14 transcripts | ||||
| 208782_at | FSTL1 | follistatin-like 1 | −1.6579 | 0.0003 |
| 201059_at | CTTN | cortactin | −1.2817 | 0.0015 |
| 201906_s_at | CTDSPL | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like |
−1.3795 | 0.0025 |
| 1555659_a_at | TREML1 | triggering receptor expressed on myeloid cells-like 1 |
−1.0767 | 0.0034 |
| 212667_at | SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | −1.214 | 0.0048 |
| 216956_s_at | ITGA2B | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) |
−1.0689 | 0.0048 |
| 230942_at | CMTM5 | CKLF-like MARVEL transmembrane domain containing 5 |
−1.1641 | 0.0061 |
| 57588_at | SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 |
−1.3053 | 0.0063 |
| 207550_at | MPL | myeloproliferative leukemia virus oncogene | −0.931 | 0.0066 |
| 219090_at | SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 |
−1.1123 | 0.0080 |
| 208791_at | CLU | clusterin | −0.9584 | 0.0085 |
| 206494_s_at | ITGA2B | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) |
−0.7279 | 0.0087 |
| 227189_at | CPNE5 | copine V | −1.2062 | 0.0088 |
| 220496_at | CLEC1B | C-type lectin domain family 1, member B | −1.2077 | 0.0090 |
| 206493_at | ITGA2B | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) |
−0.8966 | 0.0094 |
| 206049_at | SELP | selectin P (granule membrane protein 140kDa, antigen CD62) |
−1.1642 | 0.0104 |
| 203819_s_at | IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 |
−1.2947 | 0.0123 |
| 225354_s_at | SH3BGRL2 | SH3 domain binding glutamic acid-rich protein like 2 |
−1.0895 | 0.0146 |
| 207808_s_at | PROS1 | protein S (alpha) | −1.1049 | 0.0174 |
| 207206_s_at | ALOX12 | arachidonate 12-lipoxygenase | −0.8756 | 0.0207 |
| 212813_at | JAM3 | junctional adhesion molecule 3 | −1.0454 | 0.0215 |
| 1560262_at | LRRC32 | leucine rich repeat containing 32 | −0.9376 | 0.0226 |
| 204628_s_at | ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) |
−0.968 | 0.0242 |
| 214146_s_at | PPBP | pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) |
−0.713 | 0.0243 |
| 211026_s_at | MGLL | monoglyceride lipase | −1.0027 | 0.0249 |
| 208792_s_at | CLU | clusterin | −0.8122 | 0.0266 |
| 201108_s_at | THBS1 | thrombospondin 1 | −0.9169 | 0.0276 |
| 201058_s_at | MYL9 | myosin, light chain 9, regulatory | −0.5909 | 0.0287 |
| 206390_x_at | PF4 | platelet factor 4 (chemokine (C-X-C motif) ligand 4) |
−0.9017 | 0.0296 |
| 206655_s_at | GP1BB | glycoprotein Ib (platelet), beta polypeptide | −0.8934 | 0.0317 |
| 209651_at | TGFB1I1 | transforming growth factor beta 1 induced transcript 1 |
−0.7618 | 0.0326 |
| 207414_s_at | PCSK6 | proprotein convertase subtilisin/kexin type 6 | −0.8566 | 0.0351 |
| 200665_s_at | SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | −0.8261 | 0.0410 |
| 212077_at | CALD1 | caldesmon 1 | −0.5688 | 0.0505 |
| 203817_at | GUCY1B3 | guanylate cyclase 1, soluble, beta 3 | −0.8511 | 0.0546 |
| 227088_at | PDE5A | phosphodiesterase 5A, cGMP-specific | −0.918 | 0.0571 |
| 226152_at | TTC7B | tetratricopeptide repeat domain 7B | −0.7986 | 0.0594 |
| 206167_s_at | ARHGAP6 | Rho GTPase activating protein 6 | −0.8437 | 0.0677 |
| 37966_at | PARVB | parvin, beta | −0.7708 | 0.0717 |
| 208601_s_at | TUBB1 | tubulin, beta 1 | −0.5959 | 0.0736 |
| 204115_at | GNG11 | guanine nucleotide binding protein (G protein), gamma 11 |
−0.5622 | 0.1229 |
| 241133_at | PRSS1 | protease, serine, 1 (trypsin 1) | −0.4814 | 0.1243 |
| 203680_at | PRKAR2B | protein kinase, cAMP-dependent, regulatory, type II, beta |
−0.5049 | 0.1365 |
| 205442_at | MFAP3L | microfibrillar-associated protein 3-like | −0.4724 | 0.1385 |
| 212151_at | PBX1 | pre-B-cell leukemia transcription factor 1 | −0.6059 | 0.1729 |
| 212573_at | ENDOD1 | endonuclease domain containing 1 | −0.7276 | 0.1735 |
| 230690_at | TUBB1 | tubulin, beta 1 | −0.578 | 0.1864 |
| 230645_at | FRMD3 | FERM domain containing 3 | −0.6391 | 0.2102 |
| 225974_at | TMEM64 | transmembrane protein 64 | 0.38321 | 0.2227 |
| 1553842_at | BEND2 | chromosome × open reading frame 20 | −0.5657 | 0.2258 |
| 228708_at | RAB27B | RAB27B, member RAS oncogene family | −0.4836 | 0.2512 |
| 227180_at | ELOVL7 | ELOVL family member 7, elongation of long chain fatty acids (yeast) |
−0.3943 | 0.2823 |
| 212148_at | PBX1 | pre-B-cell leukemia transcription factor 1 | −0.3139 | 0.2970 |
| 203414_at | MMD | monocyte to macrophage differentiation-associated | −0.4287 | 0.3236 |
| 1552773_at | CLEC4D | C-type lectin domain family 4, member D | 0.37545 | 0.3543 |
| 222717_at | SDPR | serum deprivation response (phosphatidylserine binding protein) |
−0.3009 | 0.3830 |
| 224823_at | MYLK | myosin, light chain kinase | −0.2911 | 0.4644 |
| 214974_x_at | CXCL5 | chemokine (C-X-C motif) ligand 5 | −0.1621 | 0.5011 |
| 229778_at | C12ORF39 | chromosome 12 open reading frame 39 | −0.2032 | 0.5020 |
| 235331_x_at | PCGF5 | polycomb group ring finger 5 | 0.22781 | 0.5470 |
| 212651_at | RHOBTB1 | Rho-related BTB domain containing 1 | −0.2395 | 0.5755 |
| 206110_at | HIST1H3H | histone cluster 1, H3h | −0.2021 | 0.5827 |
| 215779_s_at | HIST1H2BG | histone cluster 1, H2bg | −0.2623 | 0.5896 |
| 207815_at | PF4V1 | platelet factor 4 variant 1 | −0.0927 | 0.6139 |
| 226188_at | LGALSL | lectin, galactoside-binding-like− | 0.23728 | 0.6142 |
| 221556_at | CDC14B | CDC14 cell division cycle 14 homolog B (S. cerevisiae) |
−0.2127 | 0.6530 |
| 207156_at | HIST1H2AG | histone cluster 1, H2ag | −0.1534 | 0.6882 |
| 210387_at | HIST1H2BG | histone cluster 1, H2bg | −0.1494 | 0.6906 |
| 225166_at | ARHGAP18 | Rho GTPase activating protein 18 | 0.15541 | 0.7353 |
| 206272_at | RAB4A | RAB4A, member RAS oncogene family | 0.09962 | 0.7967 |
| 210986_s_at | TPM1 | tropomyosin 1 (alpha) | 0.08749 | 0.8404 |
| 227451_s_at | C6ORF79 | chromosome 6 open reading frame 79 | −0.0134 | 0.9791 |
*
= the beta coefficient for the expression of either the aggregate expression of the ARS or each probe set represented by the ARS using the combined HV1 and HV2 datasets from a regression model containing gene expression and cohort (HV1 vs. HV2) with corresponding p-value; PFS = platelet function score.