Table 1.
Neurodevelopmental Impairment Definitions and Outcomes by Epoch at 18 Months Adjusted Age of Children Enrolled in Candida Study who Survived to Follow-Up
| Variable | Epoch 1 (N=544) | Epoch 2 (N=522) |
|---|---|---|
| Neurodevelopmental Impairment Definitions | ||
| Child has any of the following: | ||
| Neurological | Moderate to severe cerebral palsy with GMFCS level ≥ 2 | Moderate to severe cerebral palsy with GMFCS level ≥ 2 |
| Development | Bayley II MDI < 70 or PDI < 70 | Bayley III cognitive < 70 or GMFCS level ≥ 2 |
| Vision | Bilateral blindness with no functional vision | Visual acuity < 20–200 bilateral |
| Hearing | Bilateral amplification for permanent hearing loss | Permanent hearing loss that does not permit the child to understand directions of examiner and communicate despite amplification |
| Neurodevelopmental Outcomes | Epoch 1 N (%) |
Epoch 2 N (%) |
P |
|---|---|---|---|
| Neurodevelopmental Impairment | 222 (41) | 59 (11) | < .001 |
| Visually impaired | 5 (1) | 5 (1) | .948 |
| Hearing impaired | 16 (3) | 17 (3) | .783 |
| Moderate/severe cerebral palsy | 42 (8) | 19 (4) | .004 |
| Any cerebral palsy | 85 (16) | 49 (9) | .002 |
| Gross motor function level ≥ 2 | 44 (8) | 27 (5) | .056 |
| MDI | |||
| < 70 | 189 (35) | -- | -- |
| 70–85 | 166 (31) | -- | -- |
| > 85 | 187 (35) | -- | -- |
| PDI | |||
| < 70 | 127 (24) | -- | -- |
| 70–85 | 136 (25) | -- | -- |
| > 85 | 277 (51) | -- | -- |
| Cognitive | |||
| < 70 | -- | 42 (8) | -- |
| 70–85 | -- | 167 (32) | -- |
| > 85 | -- | 313 (60) | -- |
| Language | |||
| < 70 | -- | 82 (16) | -- |
| 70–85 | -- | 159 (31) | -- |
| > 85 | -- | 269 (53) | -- |